LOUISVILLE, Ky. (AP) Trevor Lawrence overcame two early interceptions to throw three touchdown passes, Travis Etienne rushed for 192 yards and a score and No. 3 Clemson routed Louisville 45-10 on Saturday for its 22nd consecutive victory.

Darien Rencher and Chez Mellusi added rushing TDs for the Tigers (7-0, 5-0 Atlantic Coast Conference), who missed first-quarter chances to build a big lead when Lawrence was picked off twice near the goal line. The sophomore quarterback settled down to hit Joseph Ngata and Justyn Ross with second-quarter TDs for a 17-3 halftime lead.

Lawrence's 10-yard TD to Cornell Powell made it 31-3, and he finished 20 of 29 for 233 yards.

The Tigers also posted six sacks and kept Louisville (4-3, 2-2) out of the end zone until Javian Hawkins' 3-yard TD late in the game. Clemson outgained Louisville 551-263 and improved to 6-0 all-time against the Cardinals.

Hawkins had 129 yards on 26 carries, but Louisville never got closer than 10-3 after winning its previous two games.

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Clemson hosts Boston College on Oct. 26.

Louisville hosts Virginia on Oct. 26.