DURHAM, N.C. (AP) Tommy DeVito threw for two touchdowns and rushed for another, and Syracuse beat Duke 49-6 on Saturday to snap a four-game losing streak.

Andre Cisco returned an interception 48 yards for a TD to help the Orange (4-6, 1-5 ACC) earn their first win against a power-conference team. Syracuse, a 10-point underdog, pulled away by turning three second-half takeaways into touchdowns and outscored Duke 35-0 after halftime.

Moe Neal rushed for 115 yards and a 2-yard score, Jarveon Howard also finished with 115 yards rushing with a 28-yard TD and the Orange had a season-best 286 yards on the ground. 

DeVito was 6 of 15 for 105 yards with an 18-yard scoring pass to Trishton Jackson and a 22-yarder to Luke Benson to go along with his 1-yard scoring run.

Perhaps more importantly for DeVito, Syracuse - which allows an FBS-worst five sacks per game - was sacked only once.

AJ Reed kicked field goals of 31 and 51 yards for the Blue Devils (4-6, 2-4), who lost their fourth straight.

UP NEXT

Syracuse: Plays at Louisville on Saturday.

Duke: Visits instate rival Wake Forest on Saturday.