BLACKSBURG, Va. (AP) - Trevor Lawrence had two touchdown runs and threw a scoring pass and No. 4 Clemson beat Virginia Tech 45-10 on Saturday to set up a rematch against No. 2 Notre Dame in the Atlantic Coast Conference championship game.

The Tigers (9-1, 8-1) ended their regular-season schedule with a chance for a sixth consecutive conference title and revenge against Notre Dame after a 47-40 loss in South Bend on Nov. 7 when Lawrence was sidelined by COVID-19.

Against the Hokies (4-6, 4-5), Lawrence completed 12 of 22 for 195 yards with an interception. He ran for 41 yards.

Clemson took a 17-10 lead in the second quarter on Lyn-J Dixon's 19-yard touchdown run, and added 28 more in the second half, with Lawrence scoring on a 7-yard run and throwing a 65-yard touchdown pass to Cornell Powell.

Derion Kendrick returned a fumble 66 yards for a touchdown, and the Tigers scored off another turnover.

Virginia Tech played three quarterbacks because of injuries, turned the ball over three times and rushed for a season-low 131 yards.

POLL IMPLICATIONS

The Tigers should remain at No. 4 in The Associated Press poll and should stay in the top four of the College Football Playoff rankings.

UP NEXT

Clemson: Vs. Notre Dame in the ACC championship came on Dec. 19 in Charlotte, North Carolina.

Virginia Tech: Hosts Virginia next Saturday in the regular-season finale.